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A model that most accurately recapitulates the in vivo disease state is an essential part of any clinical or research investigator’s repertoire to better understand the pathogenesis and develop potential therapeutics. Some years after the initial outbreak of the SARS epidemic in Asia, researchers identified an animal model susceptible to coronavirus that mimicked many clinical symptoms seen in humans. While the recent emergence of SARS-CoV-2 and the pandemic that followed have resulted in significant global morbidity, mortality, and societal disruption, scientists were able to use this animal model and much of what they learned previously. As the etiology of COVID-19 stems from virus-host interactions, an understanding of this biology may potentiate therapeutic insights.
In this GEN webinar, our guest presenter will tell us how she and her colleagues used a broad range of small animal models to understand the host response to SARS-CoV-2. Moreover, the presentation will focus on the strengths of the golden hamster model in studying transmission, intrahost viral dissemination, pathology, and its utility in screening for effective antivirals.
A live Q&A session followed the presentation, offering you a chance to pose questions to our expert panelist.
Webinar produced with support from:
Doctoral Candidate
Icahn School of Medicine at Mount Sinai
