Spatial Phenotyping of the Tumor Microenvironment for Characterizing Tertiary Lymphoid Structures

Advances in cancer immunotherapy suggest that tumor-infiltrating lymphocytes (TILs) are critical for the elimination of tumor cells and maintenance of effective immunosurveillance. Spatial phenotyping is a key element of these studies because identifying and characterizing the crosstalk between TIL sheltered in on tertiary lymphoid structures (TLS) is critical to understanding how anti-tumor immunity is generated in the tumor microenvironment (TME) to drive patient survival.

In this GEN webinar, our distinguished presenter, Dr. Karen Willard-Gallo, will share her study findings on TLS, T follicular helper cells (Tfh), and B cells in human breast cancer. Her research reveals how multiplex imaging can be integrated with other immunological and molecular techniques to dissect the composition of tertiary lymphoid structures, show how they promote important immune interactions linked with function/suppression in the TME and their relationship to clinical outcome in patients.

A live Q&A will followed the presentation, offering a chance to pose questions to our expert panelist.