The new Cypher VRS1250 video-rate atomic force microscope (AFM) is twice as fast as the first-generation Cypher VRS, with the ability to scan rates up to 1250 lines/second and frame rates up to 45 frames/second. The new microscope was designed to enable researchers to capture nanoscale details of dynamic events that were previously inaccessible, including biochemical reactions, 2D molecular self-assembly, and etch and dissolution processes, and more. The Cypher can also support a full range of modes and accessories that are not limited to just high-speed imaging, which allows it to be accessible to large interdisciplinary research groups and shared imaging facilities with multiple projects.