An observational study involving more than 200,000 participants has linked regular use of proton pump inhibitor drugs that are commonly used for treating acid reflux, peptic ulcers, and indigestion, to a heightened risk of developing type 2 diabetes. The results also indicated that the risk of type 2 diabetes increased with duration of PPI use, prompting the investigators to advise that physicians should exercise caution when prescribing such drugs, and weigh up the pros and cons, particularly if they are to be used over the long term.