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November 1, 2013 (Vol. 33 , No. 19)

Sugar Transferase for Glycoproteins

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An alpha-2,6-sialyltransferase is available for in vitro sialylation of glycoproteins and complex molecules in the form of human monoclonal antibodies. The enzyme, which is offered for research and pilot-scale applications in biopharmaceutical manufacturing, is designed to deliver up to 95% bi-antennary sialylation of N-linked glycan chains within six to eight hours. It is produced under animal-origin-free conditions. The alpha-2,6-sialyltransferase, which is based on a human genome sequence and expressed in mammalian expression systems, complies with quality-by-design standards, and is meant to be the first in a series of glycoengineering products.

  • Roche
  • 9115 Hague Rd
  • Indianapolis IN, 46250

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