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August 1, 2017 (Vol. 37 , No. 14)

Microencapsulation Droplet System

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Dolomite Bio

The Telos® droplet system, designed for high throughput and easy scale up, provides scientists with excellent modular component process control system, and the ability to choose from a range of particle diameters between 10–50 µm on a single piece of hardware. PLGA, or poly(lactic-co-glycolic acid), is a copolymer commonly used for drug microencapsulation. Precise manipulation of particle size, shape, and architecture is extremely important to the efficacy of the candidate drug. However, conventional emulsion-based batch methods result in uneven API distribution and particle polydispersity, requiring additional size-selection and leading to low particle yields and significant loss of API. Dolomite’s continuous flow microfluidic method overcomes these obstacles, providing almost 100% encapsulation within precisely controlled, monodisperse PLGA particles, in a single reproducible step.

  • Dolomite Bio
  • 156 Norwell Avenue
  • Norwell MA, 02061

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