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August 28, 2013

Eye on Cancer Biomarkers

This insightful analysis of publications shows research trends and putative signatures for different cancer types.

Eye on Cancer Biomarkers

Several hotspot maps on subjects such as the correlation of cancer types appear in this report, available for download below.

  • Our goal for this analysis was to ask questions such as:

    • What is the growth rate of publications focused on specific cancer or biomarker classes?
    • How are selected cancer types associated with each other?
    • Which molecular entities are “associated” with specific disease types?
    • Which combination[s] of molecular entities can provide a unique signature for specific disease types?
      • Can the publications dataset predict which signatures are most promising as biomarkers?

    In order to answer the questions, we first…

    • built a broad database of cancer biomarker publications using PubMed data, and then
    • categorized and segmented the database into 36 cancer types and 441 molecular entities.

    CLICK HERE to download the PDF report.

  • NEW: Ask the Biotech Analyst!

    Got a question about cancer biomarkers? Dr. Razvi, co-author of this report, is available to answer your questions!

    Simply submit your question in the Readers' Comments box below by no later than Wednesday, September 4, and keep your eyes peeled for a special GEN News Highlight where we will present Dr. Razvi's answers!

Posted 9/4/2013 by Sunya Bhutta

Can you perform this analysis with other disease classes—such as CNS disease, autoimmune disease, cardiovascular disease or is this analysis restricted only to cancer?

Posted 9/4/2013 by Jose Carlos Diez-Masa

A very interesting study. Most of the molecular entities associated to cancer provided in the study are genes. Could you provide information about molecular entities related to cancer that are proteins?

Posted 9/3/2013 by Patrice Bartell

How does one test your predictions—your predictions of biomarker signatures associated with specific cancers?

Posted 8/30/2013 by Mohan Karkada

Dr. Razvi, Very interesting and educating report. I guess the bias is reduced a lot when you incorporate findings from so may published reports. Is there a full report?, for example, similar to the example of breast cancer shown in the report, how does ovarian cancer bio-markers look like? Just curious!

Posted 8/29/2013 by Melinda Kucsera

How does the analysis of the entire body of scientific literature in the cancer biomarkers field allow you to make predictions regarding the association of a particular set of biomarkers with a particular cancer class or classes?

Posted 8/29/2013 by Tamlyn Oliver

Why do you believe that PubMed is a good source of publications for this analysis? Are there any other more relevant databases?


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