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September 1, Vol. 27, No. 15

  • Feature Articles

    • Operating Costs for Regional Clusters
    • John Boyd
    • A new corporate location study compares the cost of doing business for the bioscience industry in 34 US and Canadian cities The study, prepared by the The Boyd Company (wwwtheboydcompanycom), focuses on all the major cost drivers for this sector ... more »
    • Malaysian Gov't Fosters Biotech Growth
    • Robert Yuan, Ph.D.
    • Malaysia has long aspired to become a regional hub for innovative pharmaceutical and biotechnology companies The country is well endowed with natural resources in agriculture, minerals, and oil and has an established manufacturing base for consumer electronics and IT Malaysia ... more »
    • Accelerator MS Is a Powerful New Tool
    • Kate Marusina
    • To meet investor expectations and to achieve annual growth rates of 10%, each major pharma company must launch four new chemical entities (NCEs) per year, each with average annual sales of $350 million However, the industry launches fewer than one ... more »
    • Advancing Most Promising Compounds
    • Elizabeth Lipp
    • In medicinal chemistry, getting a read on toxicity earlier on in the drug discovery process is critical, said Jefferson Tilley, senior director, discovery chemistry at Hoffmann-LaRoche (wwwrocheusacom) “Toxicity is an issue, consequently there is a high attrition rate”... more »
    • Use and Support of Forensics Flourishes
    • Gail Dutton
    • The biggest change in DNA forensics may be the level of support it is gaining Yet, automation, new techniques, and tie-ins to drug development also are bolstering its advancement, as labs work to whittle away a case backload that, in ... more »
    • Transforming Transfection Technology
    • Patricia Fitzpatrick Dimond
    • Researchers and companies are devising promising approaches to circumvent limitations of existing transfection technologies Ongoing challenges, particularly with regard to high-quality recombinant human protein production, include cell-type specific requirements for most methods, length of time and cost of creating stable ... more »
    • Techniques to Ramp Up Protein Purification
    • Vicki Glaser
    • Maximizing the robustness of downstream protein purification processing can have a major impact on the economics and resource utilization of industrial-scale biopharmaceuticals production This was one of the take-home messages at the recent Barr Enterprises’ “Prep-2007” symposium held in Baltimore... more »
    • Stem Cell Firms Struggle for Financing
    • Gail Dutton
    • Venture capitalists say that they are very interested in stem cells but not enough to start funding stem cell companies Right now, the business case for investment isn’t there “Great science doesn’t equal great business,” points out Gregory A Bonfiglio, ... more »
    • Molecular Imaging in Drug Development
    • Amit Agarwal
    • Molecular imaging is becoming a very interesting growth area in drug discovery There is considerable enthusiasm in the preclinical market to expand the use of molecular imaging and a more cautious approach in the clinical market The size of the ... more »
  • Columns

    • Is Biomass the New Texas Tea?
    • Peter Lauro
    • Until the invasion of Iraq, it seemed that the US had little motivation to curb its voracious appetite for oil (aka black gold or Texas tea) The oil crisis during the 1970s was perhaps the last time the country was ... more »
    • Corning Targets Screening & Cell Growth
    • Carol Potera
    • Corning Life Sciences is the oldest operating business of its parent company, Corning (wwwcorningcom) It has been supplying scientific laboratory products for more than 90 years, starting with the invention of Pyrex® glassware Since then, 6,000 scientific products have been ... more »
    • VC Funding Trends for Life Science Firms
    • Robert Dellenbach
    • Healthcare venture capitalists have been busy this year, at least their limited partners’ dollars have The numbers have never been better What does that mean for private biopharmaceutical, medical device, and other life science companies seeking funding in 2007? Here’s ... more »
  • Tutorials

    • Amplification of RNA from FFPE Tissues
    • Paul Siebert
    • Most clinical tissue samples are preserved using formalin fixation followed by embedding in paraffin By some estimates, almost 90% of tissue sections are prepared using this methodology Although this process is excellent for maintaining morphological features, it does not preserve ... more »
    • Ligand Enrichment and Profiling Method
    • Lyle Rice
      Debra Cen
    • Proteomics holds the promise of new diagnostic and therapeutic applications to improve patient care in various areas such as cancer, cardiovascular disease, autoimmune diseases, and neurological disorders Currently over 50% of the biotech and pharmaceutical markets are generated from products ... more »