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May 15, Vol. 27, No. 10

  • Feature Articles

    • Kinase Assays' Therapeutic Potential
    • Lloyd Dunlap
    • Kinases are enzymes that catalyze the transfer of phosphate groups from high-energy donor molecules to specific target molecules These intracellular phosphorylation cascades initiated by protein kinases are the most important signaling events in eukaryotic cells, says Wen-Chieh Laio, PhD, research ... more »
    • miRNA's Role Rises in Drug Research
    • Kathy Liszewski
    • Analyzing gene expression can provide a roadmap for deciphering the role of specific genes or elaborating critical players in functional metabolic pathways Companies are pursuing solutions to better understand and define the role of gene expression especially as it relates ... more »
    • Mass Spec Protein Analysis Strategies
    • K. John Morrow Jr.
    • Proteomics arrived on the biotech scene a decade ago, promising a new discovery route to disease markers Much more complex than genomics, it represents the industrial-scale analysis of the vast array of proteins in their myriad configurations It was assumed ... more »
    • Improving Yields in Oligo Manufacturing
    • Vicki Glaser
    • The therapeutic oligo landscape has certainly become more diverse in recent years siRNA, siDNA, aptamers, immunostimulatory sequences, and miRNAs have joined the ranks of antisense oligos in developmental pipelines Thus, defining synthesis, improving purity, and reducing manufacturing costs are growing ... more »
    • Probing the Biology of Cancer Stem Cells
    • John Wong
    • Basic research in cancer stem cells erupted over the last couple of years as a result of the growing body of scientific evidence proving that these cells do exist in many cancers This fervid interest in cancer stem cell research ... more »
    • Pharmacovigilance Impacts Drug Safety
    • Mike Mentasana
    • A subtle conflict lives at the heart of the public’s faith in the pharmaceutical industry: Patients base their faith in medicines upon the idea that clinical trials and regulatory approval firmly establish drug safety The fact is, however, that neither ... more »
  • Columns

    • CVBT Banks on Fibroblast Growth Factor
    • Carol Potera
    • CardioVascular BioTherapeutics (CVBT; wwwcvbtcom) was founded in 1998, soon after Thomas Stegmann, MD, demonstrated that fibroblast growth factor injected into the hearts of patients with coronary heart disease stimulates new blood vessel growth Dr Stegmann, a cardiac surgeon in ... more »
    • Sangamo Poised to Earn Steady Revenues
    • Querida Anderson
    • Sangamo Biosciences (wwwsangamocom) is set to have a groundbreaking year, according to Pamela Bassett, senior vp life sciences research at Cantor Fitzgerald “It is our opinion that the Sangamo business model establishes a structure for long-term revenue streams from ... more »
    • Drug Delivery Fuels Specialty Pharma
    • Felix Theeuwes
    • Back in 1970 when I joined the pharmaceutical industry, the preferred company model was called a FIPCO (fully integrated pharmaceutical company), driven almost exclusively by chemical innovation, that is, the synthesis of new chemical entities While innovation and product development ... more »