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October 15, Vol. 26, No. 18

  • Feature Articles

    • BioMarket Trends
    • Over $1 billion in annual revenue is generated from tests developed to diagnostically measure proteins in plasma However, only a small number of proteins are routinely measured in plasma for diagnostic purposes While the plasma proteome holds the promise of ... more »
    • Company Update: Sequencing Technology Applicatio...
    • For the past twenty-five years, Applied Biosystems (wwwappliedbiosystemscom) has been recognized as a leading manufacturer of laboratory instruments for biotechnology and pharmaceutical researchers In 1982, it developed the first protein sequencer, followed by the first successful DNA sequencer a year ... more »
    • Maximizing Discovery Using Kinase
    • Kinases play a key role in many cellular signaling pathways and in several diseases, such as cancer and inflammation Kinase inhibition assays comprise about 20–30% of current high-throughput screening drug discovery programs Some of the most current technologies were discussed ... more »
    • Microarrays Find their Way into the Clinic
    • Microarrays have been a mainstay of the scientific research community for nearly a decade but given the more stringent demands for accuracy and reliability, have not been as closely embraced in the clinical arena Arrays are, however, finding clinical applications ... more »
    • Microrarray Standards Are the Next Step
    • Elizabeth Lipp
    • Over the course of the last 10 years, the development of microarray technology has had significant influence on gene-expression research However, it is experiencing the same growing pains that any new and upcoming technology faces—lack of reproducibility, repeatability, and comparability ... more »
    • Get Quality and Quantity in Your Process
    • Angelo DePalma
    • Because it covers such a broad end-use range from single-cell assays through mega-processing, one could say that as cell culture goes, so goes biotechnology Among the emerging, perennial trends in cell culture are automation, disposable systems, the ongoing evolution of ... more »
  • Columns

    • Telemedicine Enables Better Care
    • The concept of connected health, or telemedicine, extends healthcare beyond the traditional confines of hospitals and doctors’ offices to our everyday surroundings The availability of technology in the home, our aging population, and the dramatic increase of patients with chronic ... more »
  • Tutorials

    • Flexible Protein Microarray Inkjet Printing
    • Since their inception in 1995, DNA microarrays have become the icon of the genomics revolution Everyone with any interest has become familiar with the images of precise rows and columns of colored spots denoting levels of gene expression and latterly ... more »
    • Streamlining HTS for Challenging Targets
    • Adenine and guanine nucleotides are interconverted by diverse proteins of therapeutic interest, including kinases, phosphodiesterases, membrane transporters, DNA-modifying enzymes, and molecular chaperonins Detection of nucleotide products, usually via radioassay or coupled enzymatic assays, has traditionally served as a convenient generic ... more »
    • Rotating Bioreactors for Manufacturing
    • For most investigators the culture of mammalian cells has meant the use of traditional flasks or dishes While this technique has proved useful for many studies, it is widely recognized that cells grown in a 2-D environment tend to dedifferentiate ... more »