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August 1, Vol. 26, No. 14

  • Feature Articles

    • BioMarket Trends
    • Last year saw the global pharmaceutical market grow to $602 billion, up 77% from 2004 North America contributed 441% of global pharmaceutical sales in 2005 The three major pharmaceutical regionsNorth America, Europe, and Japanaccounted for 823% of the world market... more »
    • TechNote: Ca2+ Signal Detection in HTS Operation...
    • The bivalent ion Ca2+ is a critical second messenger involved in many physiological and signal transduction processes within a cell The central role of Ca2+ in intracellular signalling, and its physical/chemical properties also makes it an attractive reporting molecule for ... more »
    • Biomarker Discovery and Identification
    • Biomarkers, typically genetic or biochemical parameters, are used as characteristic indicators to measure outcomes They have assumed increased importance in assessing drug toxicity effects in compound screens, in diagnostic assay development, and in clinical evaluations to monitor therapy and prognosis... more »
    • Multidimensional Analysis Approaches
    • Gail Dutton
    • Multidimensional chromatography and analysis was a hot topic at "HPLC 2006" The belief, outlined in detail by Peter J Schoenmakers, PhD, Van't Hoff Institute for Molecular Sciences, University of Amsterdam (wwwuvanl), is that we have reached the end of any ... more »
    • Overcoming the Critical Issues in Scale-Up
    • Susan Aldridge, Ph.D.
    • Mammalian cell products dominate the biopharmaceutical industry and will continue to do so, predicted Andrew Sinclair, managing director of BioPharm Services (wwwbiopharmservicescom), at this year's "bioLOGIC" conference, held recently in Amsterdam The top-four product types in clinical trials are monoclonals, ... more »
    • Whither Steel & Glass in a Disposable Age
    • Increasingly popular single-use bioprocessing systems are undoubtedly taking market share from conventional glass and steel stirred reactors Disposables are carving their niche in research to pilot-scale cell culture arena but for now, at least, continue to face technological hurdles in ... more »
    • TechNote: Antibiotic-Free Systems for Production
    • The use of antibiotic resistance markers to select for a successful genetic modification, such as a chromosomal insertion or a plasmid transformation, is common practice However, with increasing stringency in manufacturing regulations it is essential to ensure that the end ... more »
    • Case Study: Vaccine Production Facility Built in...
    • Aside from being established in only eleven months, Bavarian Nordic (wwwbavarian-nordiccom) views its new vaccine facility as unique because its design and technology combine the opposing requirements for aseptic production and biosafety regulations The cGMP and biocontainment facility produces 40 ... more »
    • Biopharmaceutical Approvals Review
    • This past year, the FDA broke its own record for biopharmaceutical approvals Twenty one biopharmaceutical products received original FDA approval in 2005 There were 15 FDA approvals in 2004, 20 in 2003, 13 in 2002, 11 in 2001, and 12 ... more »
    • GEN Innovations in Biotechnology
    • In addition to developing new drugs to treat various human diseases, biotechnology is well known for spawning a plethora of novel instruments, tools, and techniques to discover and manufacture those unique therapeutics as well Indeed, products and services that may ... more »
  • Columns

    • German Biotechs Embrace Reverse Mergers
    • Many private German biotech companies are facing difficulties raising capital In Germany, venture capital is increasingly only available to a small number of companies that receive relatively large funding An IPO is an option to few German late-stage companies Many ... more »
  • Tutorials

    • Versatile Tag for Cell-Based Screening
    • Until recently, the principal way to study changes in cellular protein expression levels and perform protein functional analysis was by fluorescent reporter proteins combined with automated confocal imaging systems, both of which provide the basis for high-content screening (HCS) protocols ... more »
    • Novel Technique for Biomarker Discovery
    • Biomarker discovery has become one of the major segments of proteomics research in academic, government, biotechnology, and pharmaceutical laboratories The interest in biomarkers is being driven by the anticipation that they can be used for the detection, diagnosis, treatment, monitoring, ... more »
    • Monoclonal Antibody Purification with CHT
    • Hydroxyapatite (HAP) is a crystalline material consisting of Ca2+ and PO43- groups in the lattice (Figure 1) Unlike other matrices used for liquid chromatography that are composed of reactive ligands affixed to the matrix, HAP is both the ligand and ... more »