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June 15, Vol. 26, No. 12

  • Feature Articles

    • Biomarket Trends
    • Clinical application of molecular technologies to elucidate, diagnose, and monitor human diseases is referred to as molecular diagnostics, the most exciting growth segment of the in vitro diagnostics industry today The segment has explosive potential, with multiple opportunities for entry ... more »
    • Nucleic Acid-Based Technologies Ramp Up
    • Technology development focused on generating tools to advance nucleic acid-based research for functional genomics and gene-expression analysis to drive drug discovery and development and to develop environmental-monitoring and clinical-diagnostic strategies for detecting and identifying low levels of infectious or toxic ... more »
    • Going a Label-Free Route with Biosensors
    • Molecular labels have enabled many scientific advances that would not otherwise have been possible However, labels have drawbacks They disrupt the accurate measurement of kinetic constants, particularly binding equilibria, and problems, such as antibody cross reaction or impure solutions, can ... more »
    • Focus on Mid-Densities Drives Multiplex Arrays
    • Gail Dutton
    • The maturing microarray market is less about numbers than quality of information As users complete their high-throughput, whole-genome array work, looking at hundreds of thousands of analytes, the need to focus on subsets of those analytes is building a market ... more »
    • Disposable Bioreactors Gaining Favor
    • With the rise of biotherapeutic molecules, especially antibodies, the demand for innovations in bioreactor technology has become widespread Early efforts to produce proteins expressed by bacteria, yeast, and mammalian cells in commercial quantities employed costly, re-useable hardware, requiring extensive cleaning ... more »
    • Progress Report on the NIH Roadmap Initiative
    • At its inception in 2002, the NIH Roadmap initiative (nihroadmapnihgov) was created to "identify major opportunities and gaps in biomedical research that no single institute at the NIH could tackle alone but that the agency as a whole must address" ... more »
    • Scientific Interactions Advancing in Mid-East
    • It has been noted that technology and research play a critical role in all aspects of society However, only 10% of all research is being performed by developing countries, according to a WHO report Thus, it is crucial to establish ... more »
  • Columns

    • Pain Therapeutics Takes Different Path
    • Remi Barbier started Pain Therapeutics (wwwpaintrialscom) in 1998 with the singular vision of creating the next generation of painkillers to treat severe chronic pain "It boggles my mind that the drugs in use today for severe chronic pain are exactly ... more »
    • Gilead Targets HIV & Bird Flu Markets
    • Querida Anderson
    • Gilead Sciences&#8217 (wwwgileadcom) candidate to replace cocktail drug therapies for HIV/AIDS with a single fixed-dose triple combo pill and its influenza drug, which is the only effective therapy against H5N1 bird flu virus, delivered a 75% earnings growth for ... more »
    • ID and Validation of Biomarkers
    • Many articles have been written about the state of biomarker identification and validation using gene expression and proteomics Many call for greater care and skepticism regarding biomarker identification and validation, and some paint the whole field as in crisis Even ... more »
  • Tutorials

    • Assay: Parallel Approaches to Target Identificat...
    • The sequencing of the genome for human and several other mammalian species has been completed, and the focus of genomics has now shifted to developing methods to elucidate gene functions on a genome scale Cell-based assays using human cell lines ... more »
    • Proteome Partitioning and Fractionation
    • The proteome may be a treasure trove for biomarker discovery, but it is clear that the enormous complexity and dynamic range in protein concentration (10(5)-10(11)) creates a significant challenge for today&#8217s analytical technologies, making it extraordinarily difficult to identify rare ... more »
    • Cell Density and Physiology Monitoring
    • Cell culture and fermentation are used to produce pharmaceutical products or other molecules of interest To achieve maximum efficiency or quality assessment during the synthesis of targeted products, on-line information about the active metabolic cell concentration is of crucial importance... more »