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February 15, Vol. 26, No. 4

  • Feature Articles

    • Tracking Diseases at the Molecular Level
    • Sophia Fox
    • A proprietary technology utilizing transmission electron microscopy (TEM) to obtain detailed 3-D images of the conformation of individual proteins and macromolecular complexes in biological samples is providing what Sidec Technologies (wwwsideccom) claims is unparalleled new insights into the nature of ... more »
    • Metabolomics Plays Crucial Discovery Role
    • Kathy Liszewski
    • Metabolomics is emerging as a significant player in the drug development arena Metabolomic analysis provides a biochemical snapshot of the small molecules produced during cellular metabolism, such as glucose, cholesterol, ATP, and lipid signaling molecules The exact number of human ... more »
    • In Silico Tools Streamline Drug Design
    • Gail Dutton
    • LigandScout, released this month by Inte:Ligand (wwwinteligand com), features a 3-D pharmacophore modeling approach that, according to Inte:Ligand, offers significant time savings when compared to ligand docking A pharmacophore search for millions of compounds can be performed within hours, notes ... more »
    • Target Identification Methods Advance
    • Elizabeth Lipp
    • Spring is coming, and GENs thoughts have turned to target identification and the IBC confabs that will coincide with the vernal equinox Screening to Analysis will offer talks and panels about advancing targets from discovery to lead optimization to preclinical ... more »
    • Ready-to-Play Assays, Kits, and Libraries
    • When you go to the grocery store these days, its all about convenience Food is precooked and prepackaged into meals, so you can spend time doing other things Perhaps then, it is no surprise that similar trends are occurring in ... more »
    • Large-Scale Production of Antibodies
    • Antibody processing is a complex field, demanding an understanding of bioengineering, equipment design, cell genetics, and cell culture technology As demands for large-scale antibody production levels become more intense, companies are pursuing these disciplines from a variety of perspectives... more »
  • Columns

    • In Support of Animal Study Management Software
    • Every drug candidate undergoes efficacy and preliminary safety tests in animals, which constitute the critical bottleneck in the pivotal decision process of whether to pursue full-scale preclinical development Remarkably, almost all of these animal studies are still performed by hand ... more »
    • CancerVax' Stock Rises with Merger
    • The stock price for CancerVax (www cancervaxcom) has been rising steadily this year and changed by +1970% from its close in the second week of February, prompting Zacks (wwwzackscom) drugs analyst Chris Kallos to make a buy recommendation on the ... more »
  • Tutorials

    • Assay: Miniaturized Cellular Assays
    • Gprotein-coupled receptors (GPCRs) are an important class of receptor in modern drug discovery This superfamily of receptors is highly tractable for drug discovery purposes because many of these receptors are coupled (via Gaq/11) to transient release of intracellular calcium upon ... more »
    • Next-Generation RNA Interference
    • The technology of RNA interference has rapidly evolved as a revolutionary tool for studying gene function, biological pathways, and the physiology of disease Work and refinement of the RNAi technology has exploded in recent years We now know the basic ... more »
    • Optimizing Bacterial Cell Processing
    • Bacterial cells are widely used for production of various therapeutic proteins Isolating these valuable proteins from the other material in the culture media and refolding them into their active configuration are critical steps in manufacturing recombinant biopharmaceuticals The challenge is ... more »