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September 1, Vol. 25, No. 15

  • Feature Articles

    • Preparing for a Potential Pandemic
    • Gail Dutton
    • As the influenza season approaches, health officials remain concerned about the H5N1 strain of avian flu Humans have no immunity to this strain, which is more virulent than the 1997 version that killed six people in Hong Kong So far, ... more »
    • Funding Issues Slow Establishing Biobanks
    • Anyone looking for short-term returns on investments in biobanks is bound to be disappointed In fact, such returns will not be seen for decades, according to Jan Carlstedt-Duke, PhD, dean of research at the Karolinska Institutet (Stockholm) He spoke at ... more »
    • In Silico Modeling Begins to Produce Results
    • Gail Dutton
    • In silico modeling is becoming a valuable and accurate prediction tool, despite its early, spotty reputation The increase in information from metabolomics, proteomics, and genomics projects, plus clinical data, and better integration between bioinformatics and cheminformatics, are helping researchers build ... more »
    • Prion Disease Mechanisms and Activation
    • Transmissible spongiform encephalopathies (TSEs), the diseases caused by proteinaceous infectious particles, or prions, comprise a group of fatal neurodegenerative diseases that take their name from the holes they cause in the brains of susceptible animals and humans... more »
    • Outsourcing Drug Discovery & Development
    • Representatives of some of the leading contract research organizations (CROs) overwhelmingly encourage young biotech companies to begin at least thinking about and planning for the time when they will need to outsource a variety of drug development and clinical testing ... more »
    • Whole Genome Sequencing in 24 Hours
    • DNA sequencing is a powerful technique firmly entrenched into every aspect of biological research and drug discovery Recent advances in high throughput capillary sequencing combined with the shotgun method of sample preparation made sequencing of the whole human genome a ... more »
    • Minnesota Toots Its Own Life Science Horn
    • Ever since electrical engineer Earl Bakken invented the first implantable pacemaker and founded Medtronic in the 1950s, Minnesota has been a leader in the medical device industry In addition to Medtronic, Guidant, St Jude Medical, and Boston Scientific head the ... more »
  • Columns

    • Halting the March of Unreason
    • Drunk as a lord? Not Lord Taverne of Pimlico, the sober, polymathic, and persuasive author of The March of Unreason (Oxford University Press) Although not a scientist himself, Taverne, a Queens Counsel (an especially learned barrister appointed to advise Her ... more »
    • The Scylla & Charybdis Face Integrated Genomics
    • The application of the data and technology resulting from the completion of the Human Genome Project to the development of new medicines and treatment methodologies (integrated genomics) has been anticipated with great expectancy But the technology necessary to enable integrated ... more »
  • Tutorials

    • High-Sensitivity Mutation Scanning of Tumors
    • Tumor-associated DNA has been detected, using various techniques, in the plasma of colorectal cancer (CRC) patients, including DNA with mutations in APC, TP53, and K-RAS We report a highly sensitive mutation scanning methodology for the mutational assessment of the APC ... more »
    • Enhancing System Cleanliness & Drainability
    • Cleanliness and drainability are among the most critical issues biopharmaceutical manufacturers or owner companies must confront with their process lines Owners face the prospect of losing millions of dollars each year because of improperly sloped process lines and entrapment in ... more »