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July 1, Vol. 25, No. 13

  • Feature Articles

    • Navigating Stem Cell Fact and Fiction
    • Gail Dutton
    • At a recent conference in Greece, a German researcher described his experience of being shouted down in his home country when he attempted to deliver an invited presentation on embryonic stem cells On the other side of the world, Korean ... more »
    • Developing Sophisticated Protein-Based Drugs
    • Driven by technology, protein and peptide drug exploration has been fed by the success of the human genome project, striking improvements in technologies such as mass spectrometry, advances in molecular genetics, and progress in production technologies, including advances in establishing ... more »
    • Tapping the Potential of Protein Drug Discovery
    • Although protein drug discovery is still a new field, many companies are developing sophisticated technologies to enhance its potential These companies will be presenting information on their most recent efforts at the upcoming "Drug Discovery Technology World Congress" in Boston ... more »
    • Peptide Manufacturers See Increased Growth
    • If you were to listen in at a gathering of executives from the contract peptide manufacturing sector, you might hear phrases like "extremely busy," or "saturated until well into next year," or "cautiously optimistic about the future"... more »
    • Biomagnetic Separations Move to Next Level
    • Gail Dutton
    • Merck Chimie (wwwmerckchimiefr) introduced its new 12 to 15 m monodispersed superparamagnetic beads in June at its third international meeting in San Diego According to Fabrice Sultan, PhD, sales and marketing manager, "Their COOH-modified surface is stable and provides an ... more »
  • Columns

    • Evidence-based Medicine
    • How limited healthcare budgets can best be allocated at a time of skyrocketing costs is a question that dominates global public and private discourse At the same time, expectations are high for good health, longevity, and access to innovative medicines ... more »
    • Authorized Generics: To Switch Rather than Fight
    • In Teva Pharmaceuticals Industries, Ltd v Crawford, decided this June, the US Court of Appeals for the District of Columbia, in affirming a lower court decision, has potentially changed the landscape with respect to certain aspects of the 1984 Hatch-Waxman ... more »
  • Tutorials

    • Optimized Chemical Libraries in Drug Discovery
    • New hits in drug discovery have traditionally been identified by screening a biological target with large chemical libraries that often contain more than a million compounds This random screening is both costly and time-consuming Additionally, these libraries are notorious for ... more »
    • Targeted Disruption Using Group II Introns
    • The completed sequencing of entire bacterial genomes and recent advances in genomics has allowed the identification of many genes While several genes have been characterized, the function of the majority remains unknown Bridging the gap between sequence identification and gene ... more »
    • High-Yield Single-Use Cell Culture Systems
    • Single-use cell culture systems are the hot topic of the moment, and with good reason Disposable systems, such as T-flasks, roller bottles, and bags, can offer a variety of advantages over fully instrumented bioreactors These benefits include elimination of:... more »