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June 1, Vol. 37, No. 11

  • Feature Articles

    • Systems Biology Opens the Blackest Boxes
    • Kathy Liszewski
    • Cryptanalysis, the practice of learning how to read coded messages—and doing so without having advance knowledge of the cryptographic key—occupies not just the military services and the intelligence agencies, but the life sciences, too Soldiers, spies, and biologists alike intercept ... more »
    • Better Targeting, Delivery of RNAi Therapies
    • Richard A. Stein
    • Historically, most therapeutics have been small chemicals and antibodies designed to target cellular proteins New kinds of therapeutics are emerging, however, from a better understanding of noncoding RNAs (ncRNAs), such as the microRNAs (miRNAs) and short interfering RNAs (siRNAs), that ... more »
  • Columns

    • New Peaks in Hydrophobic Bioprocessing
    • Vicki Glaser
    • The proteins emerging from bioprocessing workflows are more complex and diverse than ever Consequently, they are proving harder to isolate and purify from mixtures Yet even closely related proteins have differences that allow them to be separated from each other... more »
    • Transforming the Organ Tissue Model
    • Gail Dutton
    • The microHeart ® and microBrain ® microtissues developed by StemoniX overcome many of the challenges associated with tissues developed from human induced pluripotent stem cells (hiPSCs) to provide greater consistency and high degrees of functionality for high-throughput drug screening and ... more »
    • Insights
    • A recent decision by the US Court of Appeals for the Federal Circuit (CAFC) will have a far-reaching effect on biopharma patent cases with its interpretation of the “on-sale bar” to patenting contained in the America Invents Act (AIA)... more »
    • Advertorial: Iowa Seeks to Lead $250B Biochemica...
    • It’s time to get back to our natural roots—literally, the roots or stocks of crops that are normally removed from the field after harvest can and should be processed into biochemical properties The beautifully complex chemistry found in nature is ... more »