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February 15, Vol. 32, No. 4

  • Feature Articles

    • Coupling SPR Increases Value
    • Kathy Liszewski
    • Surface plasmon resonance (SPR) is not the new kid on the block It’s been an industry workhorse technology for more than 20 years What is new is coupling this premier technology with thermodynamic methodologies or molecular dynamics simulations When used ... more »
    • Aiming to Optimize qPCR Steps
    • Michael D. O'Neil
    • Progress in real-time quantitative PCR (qPCR) technology has been steady since its invention approximately 15 years ago Recent innovations and where the technology is headed in the future will be discussed at a Select Biosciences’ upcoming conference on “Advances in ... more »
    • miRNA Closes In on Therapeutic Potential
    • Diana Gitig, Ph.D.
    • microRNAs (miRNAs) are short stretches—about 22 nucleotides long—of endogenously expressed noncoding RNA They modulate gene expression by binding to complementary sequences in mRNAs, thereby preventing translation from them, possibly by causing their target mRNAs to be degraded In metazoans, miRNAs ... more »
    • Getting the Most from Outsourced Projects
    • Gail Dutton
    • Making outsourcing an efficient and effective option for biotechnology manufacturing often is dependent upon innovation, a keen awareness of potential risks, and close collaborative relationships between CMOs and their clients Recipharm Pharmaceutical Development and PledPharma are reaping the benefits of ... more »
  • Columns

    • How Is the FDA Really Doing?
    • Henry I. Miller, M.D.
    • I read with interest—and mounting skepticism—Patricia Dimond’s Insight & Intelligence™ piece about FDA, “FDA New Drug Approvals in 2011 Outpace Recent Past,” on GEN’s website Some of its assertions and assumptions lacked essential context and disclosures... more »
    • As Fungal Infections Expand, so Does Market
    • Bruce Carlson
    • Until recently, serious fungal infections were relatively uncommon and systemic infections very uncommon, particularly in cool and temperate climatic zones In these zones, a fungal infection usually meant athlete’s foot or oral or vaginal thrush, which caused discomfort but were ... more »
    • Firm Focuses Operations on Gene Silencing
    • Carol Potera
    • Benitec, an Australian biotechnology company, holds a predominant patent position for silencing genes with DNA-directed RNA interference (ddRNAi) It is developing therapeutics to prove the validity of ddRNAi in treating cancer, infectious diseases, and disorders of the central nervous system... more »
    • Protein Production Services Come Stateside
    • Novoprotein Scientific was among the early contract manufacturers of recombinant proteins, according to Huaxing Zhu, PhD, president and CEO Dr Zhu started Novoprotein in 2004 when he saw a growing demand for protein expression, purification, and production services The company ... more »