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November 1, Vol. 31, No. 19

  • Feature Articles

    • Directing Cell-Signaling Research
    • Josh P. Roberts
    • It’s hard to imagine a biomedical field that’s not concerned with cell signaling From immunologists studying GPCRs and neuroscientists investigating amyloid plaques, to cardiologists telling their patients to avoid caffeine, knowing what’s connected to what and which kinases are phosphorylating ... more »
    • GEN's 30th Anniversary: Peptide Therapeutics
    • The Peptide Therapeutics Foundation recently reported that 131 peptide drug candidates were in development and 54 additional ones had been approved for marketing The foundation went on to note that over the past 30 years, peptides have been widely investigated ... more »
    • Green Chemistry Initiatives Take Shape
    • Gail Dutton
    • Many innovative companies are embracing green chemistry, citing environmental sustainability, increased efficiency, and lowered costs, as they develop the tools and measurements that inform the choices of solvents and reagents throughout a compound’s development and manufacturing, according to speakers at ... more »
    • Getting the Most from Process Operations
    • Angelo DePalma
    • Much has been written about volumetric productivity for therapeutic protein manufacturing processes While focusing on titer alone ignores such factors as time, facility utilization, and product quality, a good deal of basic research continues on what makes production cells tick... more »
    • Redefining High-Resolution Mass Spec
    • John Russell
    • Tradeoffs between resolution, sensitivity, and speed are inevitable in chemical analysis but strides are being taken to boost resolution and to improve “qual-quant” methods that enable researchers to identify and quantify compounds in a single workflow... more »
    • Regen Med Success Hinges on Engineering
    • Stuart Kay
    • As highlighted in the article “Engineering Regenerative Medicine’s Future” in the September 1, 2011 issue of GEN, there is international recognition among stakeholders in the regenerative medicine sector that the commercialization of novel therapeutic interventions must be expedited in order ... more »
    • Gene Therapy Briefs
    • Genevolve Vision Diagnostics developed a noninvasive molecular diagnostic for all major forms of congenital color blindness, for use by ophthalmologists and optometrists. The test, marketed under the Eyedox™ brand, involves using a noninvasive buccal epithelial cell collector to pick up ... more »
  • Columns

    • Retooling SBIR Not That Easy
    • Alex Philippidis
    • The Small Business Innovation Research (SBIR) program has been surviving on the same $2 billion per year budget since its authorization ended in fiscal 2008 thanks to three years of temporary spending fixes The program’s authorization is now set to ... more »
    • Solution Supplier Expands Offerings
    • Carol Potera
    • Qiagen was established in 1984 in Dusseldorf, Germany The company initially focused on molecular biology with its Plasmid-Kit, which reduced plasmid preparation time from a few days to two hours Then in 1996, it introduced the BioRobot 9600, a benchtop ... more »
    • Vaccine Market Revenue Growing
    • Bruce Carlson
    • Double-digit growth can’t last forever in any category, and it is likely that vaccines will prove to be no exception Vaccines will grow and will continue to be a major focus of pharmaceutical concerns, but they will grow at a ... more »