Leading the Way in Life Science Technologies

GEN Exclusives

More »

May 15, Vol. 29, No. 10

  • Feature Articles

    • Natural Resources Buoy Chilean Biotech
    • Robert Yuan, Ph.D.
    • An article in the April 1 issue of GEN described the environment for biotechnology in Chile and the various government programs intended to promote its advancement The main priority has been R&D that will strengthen the country’s major export industries, ... more »
    • New MS Tools Advance Biomolecular Studies
    • K. John Morrow Jr.
    • Mass spectrometry excels as a powerful technique to identify, quantify, and elucidate chemical substances It is notable for its accuracy and sensitivity, and as a result, new applications and advances constantly pour forth Recently launched innovative hardware and software for ... more »
    • "Greening" of Labs and Manufacturing
    • Angelo DePalma
    • The first installment of this article (see GEN, April 1, 2009) discussed the rationale and strategies for greening pharmaceutical and biotech operations, particularly at the corporate and facility level Here we examine laboratory and manufacturing initiatives that fall under the ... more »
    • Nasal Administration Methods Stake Out Niche
    • Alan Smith
    • Recent advances in drug delivery have led to significant innovations including polymer implants, transdermal patches, and sophisticated oral controlled-release formulations These technologies, although in widespread use today, were primarily developed to provide sustained delivery of drugs and thereby reduce dosing ... more »
    • Decoding Cell Communication
    • Kathy Liszewski
    • The intricate interplay of cellular signaling pathways provides a beehive of biologic activity in the nucleus Understanding how these pathways function and dysfunction not only helps trace the roots of cancers and genetic disorders but also suggests new therapeutic targets ... more »
    • Strategies for Removing Viruses from Cell Lines
    • Gail Dutton
    • Cell culture productivity has improved 50-fold during the past 20 years, leading to bottlenecks in downstream processing Increasingly high titers have further slowed processes During the same period, new agents and contamination risks have emerged that have required companies to ... more »
  • Tutorials

    • High-Speed Sample Volume Measurement
    • Chris Walsh
    • Significant sums of money have been invested in developing automated systems aimed at boosting the throughput, efficiency, and cost effectiveness of sample screening Investments made in this area are wasted, however, if the quality of the sample in a well ... more »
    • Obtaining Reliable PCR from Seed DNA
    • Les Hoffman
      Shannon Krueger
    • Plants have evolved a variety of defense mechanisms against predators and environmental challenges Among their protective devices are a myriad of compounds, some very complex in structure, that allow plants to repel pests These protective compounds include polyphenols and tannins ... more »
    • New Tool Recombineers the DNA of E. coli
    • Tim Zeppenfeld
    • In white biotechnology, microorganisms serve as industrial bioreactors for large-scale production of fine chemicals, enzymes, active pharmaceutical ingredients, agro chemicals, and food additives In particular E coli is used for the production of aromatic amino acids (eg, L-tryptophan, L-phenylalanine, L-tyrosine), ... more »