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February 24, 2011

Bruker to Buy Michrom for Nanoflow UHPLC System and CaptiveSpray Ionization Source Technology

Firm claims Michrom platforms will increase throughput, sensitivity and robustness for proteomics and other nano and capillary flow LC-MS applications.[idrutu-Fotolia.com]

  • Bruker has agreed to buy Michrom Bioresources, a privately owned Auburn, California-based firm providing advanced liquid chromatography instrumentation, accessories, and consumables for the life sciences, chemical, and applied markets. The firm’s flagship products include its Advance™ nanoflow ultra-high performance liquid chromatography (UHPLC) platform and CaptiveSpray™ Ionization sources for coupling to mass spectrometry in proteomics and life-science applications. The firm achieved revenues of about $3 million in 2010.

    “Michrom’s broad portfolio of novel technologies and high-performance products is highly complementary to our mass spectrometry products,” comments Collin D’Silva, president of Bruker’s chemical and applied markets division. “In particular, Michrom’s new high duty-cycle nanoflow UHPLC platform, along with their revolutionary CaptiveSpray LC-MS interface, together will provide our customers with significant gains in throughput, sensitivity, and robustness for proteomics and other nano and capillary flow LC-MS applications.”

    Michrom describes the Advance nanoflow platform as a splitless nanocapillary high-performance instrument designed to provide precise, reproducible separations from 100 nL/min to 50,000 nL/min with no hardware changes. The Advance nanoLC features <25 nL delay volume and operates up to 10,000 PSI (70MPa) providing the ability to run long columns for extremely high resolution and eliminating both delay and re-equilibration times. 

    The firm’s Advance CaptiveSpray Ionization source technology has been developed to provide what Michrom calls the next step in the evolution of LC/MS (0.1–100 µL/min) to bridge the operation gap in flow, sensitivity, and robustness between conventional electrospray ionization (ESI) and nanospray ionization (NSI). The technology is essentially plug-and-play, Michrom claims, requiring no cameras or xyz alignment, while providing ESI robustness with NSI sensitivity.

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