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June 15, 2013 (Vol. 33, No. 12)

Nudging Difficult-to-Express Proteins Along

  • Overcoming toxicity and poor accumulation are common themes in many unsuccessful attempts to overexpress difficult proteins such as multispanning membrane proteins. According to Genentech’s Hok Seon Kim, Ph.D., senior research associate in antibody engineering, toxicity can be suppressed and cell growth improved to normal by tightly controlling transcription. ...

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