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August 01, 2006 (Vol. 26, No. 14)

Drug Discovery: Successful Lead Optimization Strategies

Line Begins to Blur with Lead Discovery

  • Lead optimization aims at enhancing the most promising compounds to improve effectiveness, diminish toxicity, or increase absorption. Many of the technologies for lead discovery overlap with lead optimization as researchers attempt to incorporate the best drug characteristics early in the process. While the approaches taken may vary, the central ...

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