Uncovering Sequence Bias in Bacteriophage Systems Using Enzymatic DNA Synthesis

Demand for synthetic DNA is growing across multiple industries including cell and gene therapy development and biomanufacturing. Coupled with that growth is a need for genetic constructs that can, in some cases, encompass sequences that are currently difficult to synthesize and sequence. Enzymatic DNA synthesis was designed to address both of those challenges. Using the technique, scientists can rapidly generate long, complex DNA sequences without using toxic materials unlike traditional chemical synthesis.

In this GEN webinar, Konlin Shen, PhD, will discuss practical applications of enzymatic DNA synthesis technology in DNA nanotechnology. He will describe how his work in the lab of Shawn Douglas, PhD, at University of California, San Francisco relies on the technology to assemble complex genetic constructs with long randomers and repetitive sequences. During the webinar, Natasha Paul, PhD, will describe Molecular Assemblies’ Fully Enzymatic Synthesis™ (FES™) technology for generating long or complex DNA sequences for research, and how it addresses limitations of chemical synthesis.

Key topics covered during the webinar include:

• An overview of Molecular Assemblies’ enzymatic DNA synthesis technology and how it differs from conventional methods.
• Strategies for accessing hard-to-synthesize genetic sequences.
• Insights into overcoming sequence bias and constructing complex genes using FES technology.

A live Q&A session will follow the presentation, offering you a chance to pose questions to our expert panelists.