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GEN Presents An Educational And Informative Webinar

Using Chemical Biology for Epigenetics Research and Drug Discovery

  • Broadcast Date: Thursday, November 14, 2013
  • Time: 1 pm ET, 10 am PT



Over the last few years, the critical roles of epigenetic mechanisms such as histone acetylation and deacetylation in the control of gene expression and development of human diseases have been increasingly recognized. These diseases include cancer, inflammation, and central nervous system disorders.

And although enzymes involved in these regulatory reactions such as methyltransferases, demethylases, and acetetylases provide potential drug targets, their activities, as regulated in response to complex biological stimuli, remain unclear.

During this webinar, investigators will review epigenetic regulatory mechanisms and methodologies available for their characterization. In particular, development of a phenotypic assay system to directly measure Histone 3 K27 tri-methylation (Histone 3 K27me3) levels will be described. Using a unique set of biologically diverse annotated chemical compounds targeting 736 unique proteins with multiple maximally selective compounds for each target, a number of potential drug targets could be identified.

Results of drug discovery efforts aimed at finding specific compounds modulating the activity of epigenetic targets in several human disease states will also be presented.

What You Will Learn

  • How histone methylation biological systems can be manipulated and studied in cell-based assays
  • How targets, with multiple hits against each target, can be identified using target-annotated chemical probes in cell-based screens
  • How systematically designed chemical probe libraries can serve as drug discovery tools when combined with phenotypic screening
  • How a chemical biology strategy used in a phenotypic screen can reveal pathway-selective (Histone 3 K27me3) regulators

Who Should Attend

  • Scientists using cell-based assays for drug discovery
  • Scientists studying methylation or acetylation states of histone proteins
  • Chemical biologists
  • Scientists studying epigenetic control mechanisms in cancer, stem cells, immunology, neurodegenerative disorders, and metabolic diseases
  • Scientists study epigenetic mechanisms controlling gene expression and chromatin regulation at the epigenetic level

A live Q&A session will follow the presentations, offering you a chance to pose questions to our expert panelists.



  • Michelle Palmer, Ph.D.,
  • Director of Discovery
  • and Preclinical Research
  • Broad Institute of Harvard
  • and MIT
  • Yan Liu, Ph.D.,
  • Investigator
  • Human Sample Management
  • Technical Leader
  • GlaxoSmithKline


  • Tamlyn Oliver
  • Managing Editor
  • Genetic Engineering & Biotechnology News

Produced with support from