CRISPRs: Ushering in a New Age of Gene Editing
- Broadcast Date:
Thursday, February 6, 2014
11:00 am ET, 8:00 am PT
REGISTRATION IS FREE
CRISPRs, which were first described in E. coli in 1987, have since seized the attention of the global biotechnology community. Along with CRISPR-associated (Cas) proteins, these Clustered Regularly Interspaced Short Palindromic Repeats originally arose as a bacterial defense system again bacteriophages and plasmids. CRISPRs now are increasingly being used as next-generation genome-engineering tools.
Researchers have been quick to focus on their gene-editing potential, allowing them to cut DNA at precise locations—and at several sites at once, if desired—so that they can test the effects of mutations inside a cell. And companies have been founded to commercialize the technology. Because CRISPR technology is easier to use and much cheaper than current gene-editing methods that require considerable engineering, it could become the dominant technology. Unlike other tools, CRISPRs are constructed from RNA—a cheaper and easier starting material—and are able to make nicks simultaneously at more than one genomic location, allowing researchers to look at the effects of combinations of mutations. Breakthroughs in understanding the mechanisms of CRISPR/Cas technology offer great potential for biotech applications and understanding evolutionary dynamics.
Webinar participants will discuss the discovery, varieties, and applications of CRISPRs. How CRISPRs work and how they can be combined with complementary technologies will be explored. Prototypical bacterial systems where CRISPRs have been successfully used will be highlighted. The potential use of CRISPRs for preclinical applications will be analyzed, and eukaryotic genome editing will be examined. Future directions for CRISPRs development and applications will be explored.
What You Will Learn
- Current applications for CRISPRs
- How CRISPRs can be employed with other techniques to conduct targeted gene editing
- How Cas9 can be used generate transgenic animal models
- How to use CRISPRs as eukaryotic genome-editing tools
- Where CRISPRs stand in relation to the first human applications
- The broad commercial possibilities for CRISPR technology
Who Should Attend
- Genome engineers
- Plant biologists
- Molecular biologists
- Cell culture scientists
- Cell biologists
- Systems biologists
A live Q&A session will follow the presentations,
offering you a chance to pose questions to our expert panelists.