The Nexera X2 system enables analysis at pressures up to 19,000 psi. The system’s autosamplers provide near-zero carryover, a cycle time of 14 seconds, and injection reproducibility down to 0.1 µL injection volumes. Users can configure the system with a range of solvent delivery units and column ovens. In addition, its mobile phase-blending function automates mobile-phase preparation tasks. Core features of the Nexera X2 include a photodiode array detector, a dyanamic range extension calculator, peak deconvolution analysis, temperature-controlled optics, and automated solvent blending.