Cadence™ is a single-pass tangential flow filtration (TFF) product designed to optimize downstream purification steps in either single-use or re-use modes of operation. Cadence TFF systems harness a new TFF format, the Cadence module, which incorporates a fluid-path design that enables direct flow operation with a reduction in system hold-up volume. This, along with improved recovery capabilities, helps increase yield and achieve high product recovery. Cadence single-pass TFF systems do not use a conventional recirculation loop, allowing them to be coupled with other process steps.