Embryonic pluripotent cell lines are available including one disease free pluripotent cell line and 24 others with individual mutations that can give rise to several severe diseases such as cancer (breast cancer, Wilm’s tumor, and Von Hippel–Lindau syndrome), Huntington’s disease, muscular dystrophy (including CMT, FSHD, and Myotonic), and cystic fibrosis as well as some rarer genetic diseases such as trisomy 5, macular dystrophy, incontinentia pigmenti, juvenile retinoschisis, alpha thalassemia, and autosomal dominant torsion dystonia. All these cell lines are genetically unmodified and have been derived in compliance with international regulatory and ethical guidelines.