The AC Extraction Plate is designed to streamline sample preparation for LC-MS analysis of small molecules. The plate, which is based on TICE™ (Tecan Immobilized Coating Extraction) technology, can reduce the sample preparation process to a “pipette and shake” routine. The inner surface of each well in the 96-position, deep-well microplate is coated with a layer of TICE material. This coating can extract low molecular weight analytes—such as vitamin D and testosterone—from aqueous solutions, reducing the need for filtration, centrifugation, and evaporation steps. Sample preparation with the plate can also be automated, providing a walkaway solution.