ÄKTA start is designed to provide automated control of protein purification procedures, allowing the implementation of techniques such as affinity, ion exchange, desalting, and buffer exchange, and gel filtration. The system can support purification of tagged proteins, antibodies, and untagged or native proteins as well as sample clean-up. Built as a standalone system, ÄKTA start can be run using predefined protocols, built-in templates, or custom protocols. It can be controlled via a touchscreen, which can display the UV curve and other run data in real-time. Prepacked columns are offered for common applications. ÄKTA start can be used with the Frac30 fraction collector and Unicorn start control software.