Comprising five color-coded protein precipitation plates and five 1 mL deep well collection plates, the Combipack™ is designed to accelerate a traditionally troublesome procedure—protein precipitation sample preparation. The protein precipitation plate (P3) uses the CRASH method to eliminate proteins that interfere with downstream applications. The protein is denatured with acetronitrile, and the flocculant is filtered out, allowing 96 samples to be handled at one time. A dual-frit, hydrophobically treated matrix is used to prevent “wetting out” and leakage of the sample through the plate before the application of vacuum. Optional drain cap and top cap mats are available for use with vortex sample mixing.