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April 15, 2017 (Vol. 37 , No. 8)

Protein L Chromatography Resin

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Tosoh Bioscience

TOYOPEARL AF-rProtein L-650F, a Protein L resin that exhibits the highest binding capacity for antibody fragments that lack a Fc-portion (e.g., Fab, ScF Dab, etc.). This new resin offers the high binding capacity, but also has the ability to bind to antibody classes that do not have the affinity to Protein A, such as IgM and IgA. The selected recombinant protein L ligand used in the TOYOPEARL AF-rProtein L-650F resin is alkali stable and therefore able to withstand the high alkaline conditions necessary for clean-in-place (CIP). This resin exhibits stability in various solutions and over a wide pH range, as well as demonstrates excellent pressure-flow rate properties.

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  • UNITED STATES

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