A closed-loop HEPA-filtered containment glove box used for small-scale handling and weighing of active pharmaceutical ingredients in powder form is now available. The unit features interlocking transfer chamber doors, vacuum gauges, work station ionizer, lockable front access door, covered AC power source (110/220V), and optional bag-in/bag-out port. The glove box features the accessory 800-AS/SPI static ionizer for handling fine powders. The 800-AS/SPI emits negative and positive ions to prevent static build-up. The system is non-air assisted (no blower).