Acquity UPLC® CSH130 C18 and XSelect™ HPLC CSH130 C18 columns allow for the analysis and purification of peptides and for the quality of information generated by UPLC, LC, and LC-MS assays. The synthesis process for the Charged Surface Hybrid (CSH™) particles imparts a low-level positive charge to the surface of each particle. This CSH particle technology allows the columns to be used with a weaker acid modifier, which can deliver good resolving power and method sensitivity.