chipCAL enables characterization of enzyme activity within 2–10 minutes per sample, enabling high-throughput enzyme screening. In addition, chipCAL is suitable for monitoring a range of processes in the biopharma and fermentation industries. Its technology employs a flow principle whereby enzyme and substrate are passed through a thermodynamic cell simultaneously. This allows chipCAL to detect thermodynamic changes using volumes as low as 15 µL, minimizing the amount of valuable sample used per analysis. chipCAL’s microliter flow calorimetry also allows noncontact, label-free sample monitoring.