The Nexera Method Scouting System is designed to improve HPLC method development in R&D and QA/QC environments. The system is equipped with two pumps, each with a quaternary valve, and it can allow analysts to run binary gradients with 16 different solvent pairs. When combined with a high-pressure resistant column selection valve, which holds up to six conventional or UHPLC columns, the system can investigate up to 96 unique separation conditions per sample. Ultra-high-speed conditions can be transferred to conventional conditions. Dedicated Method Scouting Solution software helps automate scouting batch creation. LabSolutions software offers data browser functionality, and CLASS-Agent and Agent Report can facilitate data interpretation.