Capto Core 700 is a multimodal chromatography medium (resin) designed for intermediate purification and polishing of viruses and other large biomolecules. Capto Core 700 offers up to 100-fold greater sample loadings and higher flow rates. The medium employs core bead technology, with a ligand-activated core and inactive outer layer. The inactive outer layer excludes large molecules (Mr 700,000 [700 kDa] and above) from entering the beads, which can subsequently be collected in the column flowthrough. Smaller impurities bind to the internalized ligands, which are both hydrophobic and positively charged, resulting in multimodal binding of various contaminants small enough to enter the core.