Related to Sigma Divisions Establish Screening Technology Deals

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• HD CMOS Video Camera
• Dage-MTI
• HD-210U is a high-definition (HD) video camera for microscopy, scientific, and industrial applications. The single-chip CMOS camera delivers HD resolution (1,920 x 1,080 pixels) and full-screen video (16:9) at 60 frames per second. Dual DVI/HDMI an
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• Non-Perturbing Reagents
• Essen BioScience
• CellPlayer™ NucLight™ and CytoLight™ reagents are targeted fluorescent probes suited for long-term live-cell imaging assays. Available as both lentiviral constructs for cell delivery and pretransduced stable cell products, these GFP/RFP nuclear and
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• Correlated Microscopy Image Software
• FEI
• MAPS is modular automated processing system software for researchers who need to capture high-resolution data. MAPS software uses only image data to correlate and is compatible with any light microscope. Features in light microscopy images are used
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• Image Analysis Software
• PerkinElmer
• inForm® image analysis software is an automated image analysis package for quantifying biomarker expression in tumors and surrounding tissues. The software program is available in two packages: inForm Tissue Finder™ and inForm Cell Analysis™.
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• Cell Imaging System
• GE Healthcare Life Sciences
• The IN Cell Analyzer 2200 is a modular imaging system suitable for both investigative microscopy and automated high-content screening of organelles, cells, tissues, and whole organisms. The flexibility of the analyzer enables the system to be used
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• 96-Well Plates
• Reinnervate
• The Alvetex® Scaffold 96-well plates allow scientists to grow tumor cells in a way that mimics the way these cells grow in vivo and test the cytotoxic effect of novel or existing anticancer compounds using standard cell health assays including
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• High-Content Imaging
• TTP LabTech
• The acumen® hci (high-content imaging) can image and analyze the whole wells of 96- to 1,536-well plates at a resolution of 0.5 µm/pixel. This enables the screening of high-density plates and can facilitate assay miniaturization. It also
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• In Vivo Imaging
• PerkinElmer
• The IVIS Lumina series III benchtop imaging system integrates bioluminescence and full spectral fluorescence in in vivo imaging technologies. The platform can perform multiple modalities including photographic, bioluminescent, fluorescent imaging,
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• Transporter Knockout Cell Lines
• Sigma-Aldrich
• MDR1, BCRP, and MRP2 transporter knockout cell lines are now available that enable identification of substrate/transporter interactions without chemical inhibitors or knockdown RNAi technology. The knockout cell lines are available as assay-ready p
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• Microplate Detection Platform
• Molecular Devices
• The SpectraMax i3 platform’s base system features an integrated optical system enabling top and bottom reads for 6–384-well microplates and launches with three detection modes: luminescence, absorbance, and fluorescence. The user-exchangeable cartr
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• Image Analysis System
• Syngene
• The PXi Touch comes as a compact, ready-to-use unit with a built-in touch screen and processor. Each PXi Touch features a camera with a large fixed aperture lens, which enables scientists to capture images of faint bands or spots. The system is ava
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• microRNA Inhibitors
• Sigma-Aldrich
• Each Mission® synthetic and lentiviral microRNA inhibitor is designed for the long-term suppression of any miRNA endogenous to humans or mice, using an algorithm that evaluates all possible sequences for the design predicted to best maintain t
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• Mitochondrial Toxicity Assays
• INDIGO Biosciences
• A new series of assays called the MitoVir platform evaluate mitochondrial toxicity by examining inhibition of the ribonucleoside triphosphates that are substrates for the human mitochondrial RNA polymerase (POLRMT). The MitoVir platform is based on
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• Kidney Toxicity Panels
• Bio-Rad
• Developed through a partnership with Myriad RBM, the Bio-Plex Pro RBM assays enable the detection of multiple biomarkers in a single sample, which may reveal damage within hours of kidney injury. This early detection can improve drug testing in bot
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• Fluorescent Protein
• Allele Biotech
• mNeonGreen is a monomeric green fluorescent protein derived from the lancelet (cephalochordate) Branchiostoma lanceolatum . It has been demonstrated to perform as a fusion tag to a large number of target proteins when expressed in mammalian cells.
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• CCD Cameras
• Quantum Scientific Imaging
• The QSI RS series features a range of full-frame and interline transfer CCDs from 768x512 pixels up to 8.3MP. Dual-read rates of up to 8 MHz with USB 2.0, deep cooling to greater than 45°C below ambient and 16-bit pixel depth allow QSI RS seri
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• Nanoparticle Viewing Unit
• NanoSight
• The NS300 utilizes particle characterization technology and can visualize and measure particles in suspension in terms of size, light scattering intensity, fluorescence, and count. It does so particle-by-particle in the range 10–1,000 nm (material
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• In Vivo Imaging Agent
• PerkinElmer
• The GFR-Vivo™ 680 imaging agent allows researchers to measure glomerular filtration rate noninvasively, in vivo in animals. GFR-Vivo 680, in combination with fluorescence molecular tomography imaging, can provide a noninvasive approach to generate
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• Hematopoietic Colony Imaging System
• STEMCELL Technologies
• STEMvision™ is a bench-top instrument and computer system designed specifically for automated imaging and counting of hematopoietic colonies in the colony-forming unit assay. This system is meant to be used with MethoCult™ media and meniscus-free S
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• Rat Transgene Integration
• Sigma-Aldrich
• The CompoZr® Targeted Integration Kit-rRosa26 integrates transgenes into the Rosa26 safe harbor locus in the rat genome. CompoZr targeted integration kits employ CompoZr zinc finger nucleases (ZFNs) for precise and heritable gene knock-in, ena