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May. 15, Vol. 28, No. 10

BioBusiness
- Point of View
  - Genetic Science Confounds Students
  - Kenna Shaw, Ph.D.
  - Katie Van Horne
  - Joann Boughman, Ph.D.
  - "Half of your DNA is determined by your mother’s side, and half is by your father. So, say if you seem to look exactly like your mother and had gotten all phenotypes from her, perhaps some DNA that codes for your body and how your organs run w ... more »
- - Politically Speaking: Candidates Opine on Biotech & Health Issues
  - As Democratic voters take part in state primaries to choose a presidential candidate, the healthcare issue looms as large as ever. GEN recently asked Senators Barack Obama and Hillary Rodham Clinton about their plans for improving healthcare access ... more »
- Financial Focus
  - Mannkind Persists with Inhaled Insulin
  - Querida Anderson
  - Not too long ago a number of firms were vying for a slice of the anticipated $1 billion inhaled insulin market. Now, Mannkind (www.mannkindcorp.com) is the only company still standing in the clinical development space. Poor uptake of the first such ... more »
- Corporate Profiles
  - Symbiotic Firms Zero In on Enzymatic Tools
  - Carol Potera
  - While working at the University of Wisconsin, Madison, David Mead, Ph.D., helped to develop the technology behind TA cloning, now one of the most popular methods for cloning-amplified PCR products using Taq and other polymerases. That technology was ... more »
- BioMarket Trends
  - Demand for Novel Delivery Systems Rising
  - Bill Martineau
  - The demand for drug delivery systems in the U.S. will increase by over 10% annually to $132 billion in 2012. Growth opportunities will extend to a wide range of compounds and formulations. Oral controlled-release medication will continue to account ... more »
- Company Updates
  - Company Seeks to Shake Up Protein Analysis
  - Sophia Fox
  - Proteome Sciences (www.proteomics.com) recently concluded a worldwide licensing deal for its Tandem Mass Tag (TMT®) technology with Thermo Fisher Scientific (www.thermofisher.com). The agreement came just a few months after the firm received br ... more »
Drug Discovery
- Feature Articles
  - Mass Spec Looms Large in Discovery
  - Nina Flanagan
  - Hardware and software advances have greatly improved the reliability of mass spectrometry. In addition, its versatility and movement into the clinic has expanded the number of users and applications. Also affecting the MS market are increased effort ... more »
- - Optimizing the Profiling of Protein Kinases
  - Patricia Fitzpatrick Dimond, Ph.D.
  - Protein kinases comprise the largest family of mammalian enzymes, totaling at least 500. These ubiquitous enzymes play key roles in cellular regulation by catalyzing the reversible phosphorylation of more than 10,000 proteins. Dysfunctional intrace ... more »
- Tutorials
  - Applications of New Synthesis Technologies in Drug Discovery and Development
  - William Blake, Ph.D.
  - Andy Rakestraw, Ph.D.
  - Patti Aha
  - Moving far beyond the capabilities of traditional oligonucleotide synthesis, the advent of advanced synthesis technologies is enabling genetic constructs to be made more rapidly, accurately, affordably, and design friendly. Constructs ranging from s ... more »
OMICS
- Feature Articles
  - Applying aCGH to Molecular Diagnostics
  - Kathy Liszewski
  - Genetic aberrations that cause a gain or loss of chromosomal material are associated with mental retardation and congenital malformations and linked to development of cancer. Comparative genomic hybridization (CGH) is making strides as a powerful to ... more »
- Assay Tutorials
  - Strategy to Improve Quantitative Telomere FISH
  - Rajiv Raja, Ph.D.
  - Zuguo Li, Ph.D.
  - Yun-Ling Zheng, Ph.D.
  - Cytogenetic analysis of chromosomes provides the foundation for the clinical diagnosis of genetic disorders caused by chromosomal abnormalities. Initially, chromosome banding techniques such as G-banding were used as diagnostic tools. Banding techni ... more »
Bioprocessing
- Feature Articles
  - Oligo Production Expands
  - Vicki Glaser
  - At the upcoming “TIDES” conference in Las Vegas later this month, oligo manufacturers will discuss a range of opportunities and challenges related to the growing market for DNA and RNA therapeutics. Topics will include the application of process ana ... more »
- Tutorials
  - Obstacles to Presterilized Single-Use Filling
  - Jeff Jackson
  - The use of disposable components in downstream processing and final-fill operations is increasing as the technology for performing these steps in a single-use mode advances. This evolution has created significant demand for systems that support sing ... more »
Translational Medicine
- Feature Articles
  - ELNs Ready for Large-Scale Deployment
  - Gail Dutton
  - Electronic lab notebook (ELN) sales are growing by 30% per year in what was estimated as a $1 billion market, according to Atrium Research figures presented at SMi’s “Electronic Lab Notebooks” conference held recently in London. As such, they are be ... more »
- - Quest for Cancer Therapeutics Redirected
  - Irena Melnikova, Ph.D.
  - According to the WHO, more than 11 million people are diagnosed with cancer annually, causing seven million deaths every year—roughly 12% of all deaths worldwide. WHO estimates that by 2020 there will be 16 million new cancer cases every year. The d ... more »