GEN Exclusives

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Mar. 15, Vol. 28, No. 6

    • Point of View

      • Designing Improved Humans
      • Henry I. Miller, M.D.
      • The well-publicized use by athletes of performance-enhancing drugs including androgenic steroids and human growth hormone has gotten more people than ever before thinking and talking about the subject. But the issue is neither new nor limited to a s ... more »
      • Automating and Unifying Lab Workflow
      • Ilene Schneider
      • Streamlined operations, out-of-the-box automation, and flexibility  were key trends discussed at “LabAutomation2008,” while miniaturization continued to be important as well.  There is a need to work with smaller volumes and for miniaturi ... more »
      • Fragment-Based Approach Increases Leads
      • Elizabeth Lipp
      • Researchers are increasingly relying upon fragment-based lead discovery in their search for novel and effective drug candidates. The approach utilizes a number of complementary technologies, with crystallography and structure-based drug design being ... more »
      • Getting More Out of Poor RNA Samples
      • Kathy Liszewski
      • Analysis of RNA provides the gateway to deciphering cells’ intricate workings. Such information is critical for dissecting gene expression, biomarker analysis, and responses to therapeutics. Dealing with RNA, however, can be tricky. Degradation, limi ... more »
      • Paucity of Biopharma Approvals Raises Alarm
      • Ronald Rader
      • FDA pharmaceutical approvals in recent years, particularly in 2007, have noticeably decreased. Typically, coverage of declining FDA approvals has concentrated on pharmaceuticals in general or those regulated as drugs. This article reviews 2006 and 20 ... more »
      • Protein Microarray Uses Abound
      • Vicki Glaser
      • High-throughput proteomics using microarray-based technology and proteome chips is accelerating protein-biomarker discovery for research and diagnostic applications. Researchers are using protein microarrays to profile protein expression in normal a ... more »
      • Surmounting Small Molecule Challenges
      • Nina Flanagan
      • Companies are developing new platforms to enhance their small molecule discovery efforts and, in turn, the molecules themselves. This is due in part to increased pressure to develop new drugs. With an estimated $20 billion of brand-name drugs going o ... more »
    • Tutorials

      • Fine-Tuning Compound Safety Assessments
      • Richard Brennan
      • The significant failure rate of compounds entering clinical trials, due in large part to safety and efficacy concerns, has led the pharmaceutical industry to invest heavily in new technologies and to integrate safety assessment into the discovery an ... more »
      • Metabolic Monitoring Enhances Production
      • Bo Xu
      • Jens Gram
      • Astandardized approach for using process metabolic monitoring for enhancing microbial production of recombinant proteins is described in this tutorial by CMC Biopharmaceuticals. Implementation is based on readily available equipment such as off-gas ... more »
    • Financial Focus

      • Monogram Enters Theranostic Market
      • Querida Anderson
      • The advent of personalized medicine seems to have been upon us for a while now. Many wonder whether the buzz surpasses the reality. The scant number of individualized therapies and molecular diagnostics and prognostics on the market after decades of ... more »
    • Corporate Profiles

    • BioMarket Trends

      • Growth Foreseen for Ophthalmology Sector
      • Hermann Mucke
      • The market for prescription ophthalmological therapeutics will experience considerable and consistent growth throughout the next 10 years as demographic changes and lifestyle factors drive the need for developing safe and effective therapies for eye ... more »
    • Assay Tutorials

    • Company Updates

      • Fermentas Learned Fast How to Go Global
      • Ilene Schneider
      • Founded as part of the former Institute of Applied Enzymology, a genetic research center established and funded by the Soviet government but located in Vilnius, Lithuania, Fermentas ’ original purpose was to develop tools for molecular biology at a t ... more »

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Megamerger Dealzapoppin Poll

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