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Sep. 1, Vol. 25, No. 15

    • Point of View

      • Halting the March of Unreason
      • Drunk as a lord? Not Lord Taverne of Pimlico, the sober, polymathic, and persuasive author of The March of Unreason (Oxford University Press). Although not a scientist himself, Taverne, a Queens Counsel (an especially learned barrister appointed to ... more »
    • Legal Affairs

      • The Scylla & Charybdis Face Integrated Genomics
      • The application of the data and technology resulting from the completion of the Human Genome Project to the development of new medicines and treatment methodologies (integrated genomics) has been anticipated with great expectancy. But the technology ... more »
    • Wall Street BioBeat

      • Biotech and Pharma in a Turbulent World
      • Any number of perspectives would suggest that the business of drug development is in the midst of great evolutionary upheaval. Where historically the pharmaceutical industry has been something of a big brother to the biotechnology industry, facilit ... more »
      • Funding Issues Slow Establishing Biobanks
      • Anyone looking for short-term returns on investments in biobanks is bound to be disappointed. In fact, such returns will not be seen for decades, according to Jan Carlstedt-Duke, Ph.D., dean of research at the Karolinska Institutet (Stockholm). He s ... more »
      • In Silico Modeling Begins to Produce Results
      • Gail Dutton
      • In silico modeling is becoming a valuable and accurate prediction tool, despite its early, spotty reputation. The increase in information from metabolomics, proteomics, and genomics projects, plus clinical data, and better integration between bioinf ... more »
      • Minnesota Toots Its Own Life Science Horn
      • Ever since electrical engineer Earl Bakken invented the first implantable pacemaker and founded Medtronic in the 1950s, Minnesota has been a leader in the medical device industry. In addition to Medtronic, Guidant, St. Jude Medical, and Boston Scien ... more »
      • Outsourcing Drug Discovery & Development
      • Representatives of some of the leading contract research organizations (CROs) overwhelmingly encourage young biotech companies to begin at least thinking about and planning for the time when they will need to outsource a variety of drug development ... more »
      • Preparing for a Potential Pandemic
      • Gail Dutton
      • As the influenza season approaches, health officials remain concerned about the H5N1 strain of avian flu. Humans have no immunity to this strain, which is more virulent than the 1997 version that killed six people in Hong Kong. So far, however, only ... more »
      • Prion Disease Mechanisms and Activation
      • Transmissible spongiform encephalopathies (TSEs), the diseases caused by proteinaceous infectious particles, or prions, comprise a group of fatal neurodegenerative diseases that take their name from the holes they cause in the brains of susceptible ... more »
      • Whole Genome Sequencing in 24 Hours
      • DNA sequencing is a powerful technique firmly entrenched into every aspect of biological research and drug discovery. Recent advances in high throughput capillary sequencing combined with the shotgun method of sample preparation made sequencing of t ... more »
    • Tutorials

      • Enhancing System Cleanliness & Drainability
      • Cleanliness and drainability are among the most critical issues biopharmaceutical manufacturers or owner companies must confront with their process lines. Owners face the prospect of losing millions of dollars each year because of improperly sloped ... more »
      • High-Sensitivity Mutation Scanning of Tumors
      • Tumor-associated DNA has been detected, using various techniques, in the plasma of colorectal cancer (CRC) patients, including DNA with mutations in APC, TP53, and K-RAS. We report a highly sensitive mutation scanning methodology for the mutational ... more »
      • Utilizing a New Tool for Drug Discovery
      • There have been significant advancements in drug discovery paradigms over the past decade with the emergence of high throughput screening (HTS) technologies at the center. For a validated drug target, HTS is a powerful tool to explore chemical dive ... more »

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