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January 15, Vol. 37, No. 2

  • Feature Articles

    • Snag-Free Combing of the Proteome
    • Richard A. Stein
    • Proteomics lags behind genomics and transcriptomics, endeavors that have been accelerated by next-generation sequencing Although proteomics isn’t exactly stuck—it is chugging along thanks to mass spectrometry (MS)—it sometimes spins its wheels because the world of proteins is particularly slippery... more »
    • Just Enough Downstream Innovation
    • Angelo DePalma
    • Platform manufacturing keeps driving the industrialization of bioprocessing, both upstream and downstream Upstream operations, risk averse as ever, are using the new platform approaches to do the usual: push raw production And it must be said that downstream operations are ... more »
    • Tuning Up or Taming Immune Responses
    • Kathy Liszewski
    • Sometimes standing up to a bully requires digging in and strengthening self-defense strategies Although the immune system is well-equipped to handle most assaults, a bully, such as an opportunistic pathogen or a crafty cancer cell, may overtake immunity... more »
    • GEN Roundup: Kinase Assays from Preliminary Scre...
    • Efficient kinase assays and precision medicine go hand in hand As precision medicine becomes more of a reality, researchers are taking a closer look at the role of kinase assays As an integral aspect of kinase inhibitor therapeutics and with ... more »
    • GEN Goes “Big” on Big Data
    • In this special section, we present four articles on Big Data. Each contains big ideas from a big player—Seven Bridges discusses precision medicine research in the million-genome era; Dell, the utilization of machine-learning capabilities; Qlucore, visualization for advanced Big ... more »
    • NGS Big Data Issues for Biomanufacturing
    • Zachary Pitluk
    • The GEN Special Section on Big Data consists of four articles: Precision Medicine Research in the Million-Genome Era Utilizing Machine-Learning Capabilities NGS Big Data Issues for Biomanufacturing Visualization for Advanced Big Data Analysis ... ... more »
    • Big Data Sidebars
    • Established in 2006, The Cancer Genome Atlas (TCGA) serves as a vital compendium of genetic mutations responsible for cancer, derived using next-generation DNA sequencing Today, TCGA includes more than 25 petabytes of data collected from nearly 11,000 patients, describing 34 ... more »