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April 15, Vol. 36, No. 8

  • Feature Articles

    • Regenerative Medicine Comes of Age
    • MaryAnn Labant
    • Induced pluripotent stem cells (iPSCs) and genome-editing techniques have facilitated manipulation of living organisms in innumerable ways at the cellular and genetic levels, respectively, and will underpin many aspects of regenerative medicine as it continues to evolve... more »
    • Sink or Swim Time with ADME/Tox
    • Kathy Liszewski
    • It may sound harsh, but drug candidates that are bound to be poor performers should be identified sooner rather than later—and ruthlessly eliminated from development Granted, early in development, drugs tend to wade into the shallow end of the pharmacokinetic pool, and it ... more »
  • Tutorials

    • DNA Synthesis Steps Up
    • Devin Leake
    • Fueled by the race to the $1,000 personal genome, sequencing technologies have improved logarithmically in scale, processing time, and cost reduction, revolutionizing the life sciences industry and enabling entirely different approaches to many life science applications In fewer than 15 ... more »
    • Motion Control for Sequencing Instrumentation
    • Brian Handerhan
    • The wealth of information that DNA se quencing can provide is essential to advancing many areas of biological research, including applied fields such as medical diagnosis, biotechnology, forensic biology, virology, and biological systematics The high speed that modern DNA sequencing ... more »
    • Screening Successfully for Endotoxins
    • John Dubczak
    • The standard tool for screening endotoxins—highly toxic, heat-stable lipopolysaccharides that constitute the outer cell membrane of gram-negative bacteria—is the Limulus amebocyte lysate (LAL) test It is so-named for a compound found in horseshoe crabs that reacts with exquisite sensitivity to ... more »