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March 1, Vol. 36, No. 5

  • Feature Articles

    • Quantitative Proteomics Shifts to Hyperdrive
    • Richard A. Stein
    • In virtually every area of the life sciences, researchers rely on protein characterization Yet protein characterization misses entire dimensions of the protein universe One such dimension covers the repertoire of proteins, the identity of all the constituents of the proteome... more »
    • GEN Roundup: Digital PCR Advances Partition by P...
    • Digital PCR (dPCR) has generated intense interest because it is showing potential as a clinical diagnostics tool It has already proven to be a useful technique for any application where extreme sensitivity or precise quantification is essential, such as identifying mutations or copy number ... more »
    • Keeping Tabs on Polyhistidine Tags
    • Angelo DePalma
    • Affinity tagging, a popular method for capturing or immobilizing proteins, has several incarnations, none more popular than polyhistidine tagging In polyhistidine tagging, 6 to 10 histidine residues are added recombinantly to either the protein’s C- or N-terminus... more »
  • Tutorials

    • Faster ELISA with Better Results
    • James Murray
    • The search for biomarkers for the early detection of human diseases, such as cancer, or the identification of novel drug targets in discovery requires an assay that delivers specific, accurate, and sensitive quantification of target proteins The ideal assay uses ... more »
    • Cleaning Up CRISPR
    • Mark Behlke, M.D., Ph.D.
      Ashley Jacobi
    • Advances in gene-editing technologies have enabled scientists to push forward their understanding of human genetics, especially in the context of genetic disorders A number of different tools exist for making targeted genome modifications The CRISPR/Cas9 system is a naturally occurring ... more »