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September 15, Vol. 35, No. 16

  • Feature Articles

    • Feng Shui Basics for 3D Cell Culture
    • Lisa Heiden
    • Simply put, “cells in 3D more closely mimic the phenotype of real tissues and organs than those in 2D,” informs Jeffrey Morgan, PhD, a professor of medical science and engineering at Brown University and founder of Microtissues... more »
    • An Ear for Proteins’ Bells and Whistles
    • Angelo DePalma
    • Therapeutic proteins are subject to deamidation, oxidation, glycosylation and other post-translational modifications (PTMs) These finishing touches are not merely ornamental, they can alter essential factors such as structure (including higher-order structure), binding, stability, and activity—factors that can influence a biotherapeutic ... more »
  • Tutorials

    • Immuno-Oncology Landscape Expands
    • Dara Grantham Wright
    • For years, researchers and physicians have suspected, and have worked to demonstrate, how the immune system affects susceptibility to, defense against, and progression of certain cancers It is now understood that the immune system has the ability to influence the ... more »
    • Analysis of 3D Cell Culture Models
    • Brad Larson
    • Cancer, the uncontrolled growth of abnormal cells in the body, is a general term used to account for more than 100 types of disease According to Cancer Facts and Figures 2015, published by the American Cancer Society, nearly 600,000 US ... more »
    • Evolution of Shake Flask Technology
    • Daniel Bruecher
    • Before and for a time after the research career of Louis Pasteur, microbiology essentially remained a static task Glass bottles would rest on shelves until the contents were analyzed This all changed in 1949, when the Nobel Prize was awarded ... more »