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April 1, Vol. 35, No. 7

  • Feature Articles

    • Cancer in Cell Therapy’s Crosshairs
    • Ken Doyle, Ph.D.
    • Adoptive immunotherapy has emerged as a promising weapon in the therapeutic arsenal being mobilized to fight cancer In this approach, T cells are isolated from a patient’s tumor, genetically engineered using one of several different approaches, and infused back into ... more »
    • Fine-Combing the Cancer Transcriptome
    • Kathy Liszewski
    • Analyzing the entire cancer transcriptome or targeted transcripts with deep genetic profiling and other technologies provides a rapid and accurate means to detect potentially important expression changes Further, identifying and evaluating modifications in the RNA of tumors helps reveal not ... more »
    • Interpreting Toxicity’s Portents
    • MaryAnn Labant
    • Therapeutics fail during the discovery and development cycles for many reasons, such as bioavailability, efficacy, or toxicity Predicting low instances of toxicity, which may only emerge late in development, in clinical trials, or even after the compound is on the ... more »
    • Strategic Cell-Line Development
    • Angelo DePalma
    • ll successful cell-line engineering projects begin with a robust host cell line, one characterized by good growth and expression capabilities “If a line grows well, there is the potential that favorable characteristics will translate and be heritable for any recombinant ... more »
    • Better Tools for Improved Immuno-Oncology Resear...
    • Leon Hall
    • Our ability to understand the complexity of human cancer progression was once limited by research models that did not recapitulate the disease with full accuracy Those limitations are now behind us Thanks to advances in immune-deficient and genetically engineered mouse ... more »