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March 15, Vol. 35, No. 6

  • Feature Articles

    • Single Cell Is No Longer a Limit
    • Kate Marusina
    • Flow cytometry, a technology that takes measurements at the single-cell level, can assess phenotypic and functional parameters across diverse cell types and tissues As this technology develops, many questions that seem difficult or even impossible to address may soon be posed ... more »
    • NGS Propels Personalized Oncology
    • Lisa Heiden
    • Oncology has risen to the forefront of genomic profiling, which is being used to identify actionable driver mutations and other markers These markers can help clinicians design therapies and monitor patient responses, and they may be revealed by means of next-generation sequencing ... more »
    • A Dynamic View of Gene Expression
    • Richard A. Stein
    • Over 70 years ago, quantum physicist Erwin Schrödinger offered his thoughts on biology’s physical underpinnings, inspiring a generation of molecular biologists by suggesting that genes were information carriers He even referred to chromosomes as being the “architect’s plan and builder’s craft ... more »
    • Glycosylation: The Key to Quality
    • Angelo DePalma
    • Glycosylation of therapeutic proteins is nearly always mentioned within the context of quality and consistency Critical quality attributes (CQAs) are affected by multiple factors, including clone selection, culture and purification conditions, formulation, and storage conditions... more »