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January 15, Vol. 35, No. 2

  • Feature Articles

    • More Predictive Cell-Based Assays
    • Lisa Heiden
    • Cell-based assay platforms are evolving to meet diverse challenges—mimicking disease states, preserving signaling pathways,  modeling drug responses, and recreating environments conducive to tissue development... more »
    • Protein Expression Strategies
    • Angelo DePalma
    • Mammalian cell-based expression shows an inverse relation between cell proliferation and recombinant protein production According to Pierre-Alaiin Girod, PhD, CSO at Selexis, it is possible to redirect cellular resources from biomass accumulation to protein synthesis by altering the physicochemical environment... more »
    • Biobanking on Translational Omics
    • Kathy Liszewski
    • There is a growing consensus that next-generation biobanks are central to the realization of personalized medicine Next-generation biobanks are collecting, tracking, and maintaining a wide array of biological specimens—the very resources today’s researchers need if they are to bring about ... more »
  • Tutorials

    • Building Richer Assays
    • Blake Anson
    • Human induced pluripotent stem cell (iPSC) technology has significant potential to revolutionize biomedical research Derived from skin or blood of any individual, iPSCs provide unprecedented access to native cellular biology exhibiting healthy and disease phenotypes for basic research, drug development, ... more »
    • Biophysical Characterization of VLPs
    • Daniel Some, Ph.D.
    • Virus-like particles (VLPs) are biomolecular nanoparticles formed by controlled self-assembly of viral structural proteins Lacking viral DNA for replication, VLPs are safe yet highly immunogenic, triggering an immune response without the risk of infection... more »