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Nov. 15, Vol. 31, No. 20

BioBusiness
- Feature Articles
  - GEN's 30th Anniversary: Molecular Diagnostics
  - In this issue’s “Biomarket Trends” column, Frost & Sullivan analyst Jonathan Witonsky notes that revenues from worldwide sales of molecular diagnostics were estimated to reach $4 billion last year and to rise to $6 billion by 2014 based on a com ... more »
- Corporate Profiles
  - Samsung Stakes Out Biopharma Position
  - Carol Potera
  - Samsung, the South Korean company best known to Americans for televisions and other electronic equipment, is branching out to make biopharmaceuticals. In May, ground was broken for Samsung Biologics located in Incheon, South Korea; full-scale operat ... more »
- BioMarket Trends
  - Infectious Disease Molecular Diagnostics
  - Jonathan Witonsky
  - Molecular diagnostics are well-established in clinical medicine. Nonetheless, the markets for these tests remain one of the most attractive growth opportunities in the in vitro diagnostics industry. Approximately 600 hospital laboratories and 200 in ... more »
- Insight & Intelligence™
  - Syn Bio Delivers Cool Tools but Drugs Are a Ways Off
  - Patricia Fitzpatrick Dimond, Ph.D.
  - What does it take to transform a microbe normally found in the intestinal tract into a cancer-killing machine? These and other questions about the applicability of synthetic biology abound. For cancer research in particular, the field of syn bio cou ... more »
Drug Discovery
- Feature Articles
  - Microfluidics Making Bigger Impression
  - Vicki Glaser
  - Microfluidics technology development is entering a new phase, according to Andreas Manz, Ph.D., head of research at the Korea Institute of Science and Technology, Saarbrücken, Germany. Now that the initial patents covering the fundamental techn ... more »
- Assay Tutorials
  - Stain-Free Approach for Western Blotting
  - Ryan Short
  - Anton Posch, Ph.D.
  - Western blotting is one of the most ubiquitous procedures used in the life science research lab today. Commonly used to assess relative protein expression differences, accurate Western blot quantitation requires careful attention to procedural detai ... more »
OMICS
- Feature Articles
  - Flow Cytometry Shifting Gears
  - Kathy Liszewski
  - Although established more than 30 years ago, the field of flow cytometry continues to grow and advance. It remains an indispensable tool for clinicians and researchers. The “Northwest Regional Cytometry” meeting held earlier this year focused on cyt ... more »
- - Gene-Expression Profiling Finds Niche
  - Diana Gitig, Ph.D.
  - How can one take the measure of a cell? What most characterizes it? In this genomic age, one possible answer is that a cell can be defined by a profile of all of the genes it is expressing. Microarray technology and next-generation sequencing method ... more »
- Tutorials
  - Advances in Sophisticated Genome Editing
  - Keith Hansen
  - CompoZr® zinc finger nucleases (ZFNs) from Sigma® Life Science enable efficient and affordable gene editing across many species and cell types, including humans, rats, mice, frogs, rabbits, pigs, cattle, C. elegans , and Drosophila . Rec ... more »
Bioprocessing
- Feature Articles
  - Improving Classic Antibody Engineering
  - Angelo DePalma, Ph.D.
  - Antibody engineering holds the potential for creating antibodies with multiple specificities, greater affinity for their targets, and fewer side effects. Among these approaches, more-or-less traditional protein engineering remains a topic of intense ... more »
- Tutorials
  - Enhanced Albumin Fusion Technology
  - Jason Cameron
  - The development of efficacious protein-based therapeutics is often hindered because many exhibit a short plasma half-life. As a result, technologies addressing the extension of protein half-life are attracting considerable attention within the pharm ... more »
Translational Medicine
- Feature Articles
  - FSPs Provide an Option to Traditional CRO Approach
  - Gail Dutton
  - Companies are taking a new look at functional service providers (FSP), as they reassess their outsourcing models in the quest to continue to advance research despite constrained budgets. Now, in addition to the traditional full-service CRO, biopha ... more »