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December 1, Vol. 30, No. 21

  • Feature Articles

    • Turning Data into Genomic Medicine
    • Vicki Glaser
    • Genomic data is pouring out of academic and government research labs, flowing into rapidly expanding databases—often overwhelming storage and informatics capabilities—and fueling a steady stream of publications proposing links between the “needles” being discovered in genomic haystacks and disorders ranging ... more »
    • Multiplexing Finds Diverse Applications
    • K. John Morrow Jr.
    • While numerous challenges exist in exploring the biology of disease identification and classification via multiplexing approaches,  improvements in high-throughput technology bode well for new clinical offerings This was one of the main take-home messages at two conferences that looked at ... more »
    • Analyzing the Genome One Cell at a Time
    • Vicki Glaser
    • Early studies of gene expression in single cells revealed a greater than expected amount of heterogeneity among cells from supposedly homogeneous populations It is now well accepted that, for example, not every tumor cell, liver cell, or stem cell isolated ... more »
    • Synthetic Bio Not Yet Ready for the Market
    • Ellyn Kerr
    • In May of this year, the J Craig Venter Institute (JCVI) announced it had created the first fully synthetic, self-replicating bacterial cell ( Mycoplasma nycoides JCVI-syn10) While this proof-of-concept demonstration of an “artificial life form”  might raise justifiable fears about ... more »
    • Exploring Future of Cell-Culture Processes
    • Angelo DePalma
    • Scientists from industry and academia gathered in October to discuss biomanufacturing trends and technologies at “Cell Factories of the Future,” a symposium held at Rentschler Biotechnologie’s main facilities in Laupheim, Germany The symposium was the first in a new series ... more »
    • Biorepositories Brace For Greater Security
    • Nina Flanagan
    • Researchers in academia and industry realize the importance of biospecimens not only for diagnostics but also for drug discovery and development Unfortunately, the collection and processing of these precious assets varies from lab to lab, raising doubts about the accuracy ... more »
  • Tutorials

    • TFF Optimization with Single-Use Systems
    • Elizabeth Goodrich
    • Tangential flow filtration (TFF) is an efficient separation technology that is widely used in the downstream purification of solutions containing molecules such as recombinant proteins (including mAbs), vaccines, or cellular debris TFF has three primary applications in bioprocessing: clarification by ... more »